What are the advantages of LMWH over unfractionated heparin (UFH)?
LMWHs offer several advantages over unfractionated heparin (UFH):
- Predictable pharmacokinetics: LMWHs have a more predictable anticoagulant response, reducing the need for frequent monitoring. - Longer half-life: This allows for once or twice daily dosing, improving patient compliance. - Lower risk of heparin-induced thrombocytopenia (HIT): LMWHs are associated with a lower incidence of this serious side effect compared to UFH. - Subcutaneous administration: LMWHs can be administered subcutaneously, making them suitable for outpatient therapy.
