Ask a Clinical Question: Formulate a clear, focused clinical question using the PICO format (Patient problem, Intervention, Comparison, Outcome). Search for the Best Evidence: Use databases like PubMed and CINAHL to find relevant research articles and clinical guidelines. Critically Appraise the Evidence: Evaluate the quality of the evidence, considering its validity, reliability, and applicability to your clinical question. Integrate the Evidence: Combine the research evidence with your clinical expertise and the patient's preferences to make a well-informed decision. Evaluate the Outcomes: Assess the effectiveness of the decision or intervention and make necessary adjustments.