While both CRNAs and anesthesiologists are trained to administer anesthesia, there are key differences between the two. Anesthesiologists are medical doctors with extensive training in anesthesia, typically requiring four years of medical school and several years of residency. CRNAs, on the other hand, are advanced practice nurses who complete a graduate program in nurse anesthesia. Both professionals are highly skilled and often work together in various settings, but CRNAs are known for providing cost-effective anesthesia care, particularly in rural and underserved areas.