Low WBC counts, or leukopenia, can result from: - Bone Marrow Disorders: Conditions like aplastic anemia affect the production of white blood cells. - Autoimmune Diseases: Disorders such as lupus can cause the body to destroy its own WBCs. - Infections: Severe infections, including sepsis, can deplete WBCs. - Medications: Chemotherapy and other drugs can suppress bone marrow function. - Nutritional Deficiencies: Lack of vital nutrients like vitamin B12 and folate can lead to leukopenia.