Nurses play a crucial role in minimizing injection site pain through proper techniques and patient education. Some effective strategies include: - Using the smallest appropriate needle size. - Ensuring the medication is at room temperature. - Administering the injection slowly to reduce tissue trauma. - Using a quick, dart-like motion for intramuscular injections. - Applying a cold or warm compress before and after the injection, depending on the type of medication. - Educating patients on relaxation techniques to reduce muscle tension.