Injection site pain is a common issue that occurs when a person receives an intramuscular, subcutaneous, or intravenous injection. The primary causes of this pain include the type of medication, the size of the needle, the injection technique, and the patient's muscle tension during the injection. Certain medications, especially those that are more viscous or irritant, can cause more discomfort. Additionally, incorrect injection techniques can lead to tissue damage, resulting in pain.