1. Lack of Understanding: Patients may not fully comprehend the importance of their treatment plan or how to properly follow it. 2. Side Effects: Adverse effects from medications can discourage patients from continuing their prescribed regimen. 3. Complex Schedules: Multi-drug regimens or intricate care plans can be overwhelming. 4. Financial Constraints: The cost of medications and treatments can be prohibitive for some patients. 5. Psychological Factors: Depression, anxiety, and other mental health issues can deter patients from adhering to their care plans.