PICC lines are typically removed when no longer needed for therapy, or if complications arise that necessitate removal. The procedure is usually straightforward and can be performed by a trained nurse. It involves: 1. Removing the dressing and securing devices. 2. Gently withdrawing the catheter while the patient performs the Valsalva maneuver to prevent air embolism. 3. Applying pressure to the site to stop any bleeding and then covering it with a sterile dressing.