Crohn's disease is a chronic inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal (GI) tract, from the mouth to the anus. It leads to inflammation of the digestive tract, which can cause severe abdominal pain, diarrhea, fatigue, weight loss, and malnutrition. The inflammation caused by Crohn's disease can involve different areas of the digestive tract in different people.