Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disorder that affects the nerve cells in the brain and spinal cord. It leads to the degeneration of motor neurons, which are essential for voluntary muscle movement. As these neurons die, the brain loses the ability to initiate and control muscle movement, leading to muscle weakness, atrophy, and, eventually, paralysis.