Individuals with hemoglobin C disease (homozygous for hemoglobin C) may experience symptoms such as mild to moderate anemia, jaundice, and an enlarged spleen. The disease tends to be less severe than other hemoglobinopathies like sickle cell disease. However, individuals with hemoglobin C trait (heterozygous) usually do not exhibit symptoms and are often unaware they carry the abnormal gene.
