Preparation for the PCCN exam involves reviewing the exam content outline provided by the AACN, which includes topics like cardiovascular, pulmonary, endocrine, hematology, neurology, renal, and gastrointestinal systems. Nurses should also focus on areas such as multisystem complications, psychosocial aspects, and professional caring and ethical practice. Various study materials, courses, and practice exams are available to help candidates prepare effectively.