The calculation of a loading dose depends on multiple factors including the drug's volume of distribution (Vd), the desired plasma concentration, and patient-specific variables such as weight and age. The formula used is: Loading Dose = (Desired Concentration x Vd) / Bioavailability For example, if a drug has a Vd of 50 L and the desired plasma concentration is 10 mg/L, with 100% bioavailability, the loading dose would be 500 mg.
