Intrathecal administration is utilized for several reasons: - Pain Management: It is particularly effective for severe, chronic pain conditions that are unresponsive to other treatments. Medications such as opioids or local anesthetics are used to manage pain. - Chemotherapy: Certain types of cancer, like central nervous system lymphoma, require direct delivery of chemotherapy to the brain or spinal cord to be effective. - Infections: Antibiotics may be administered intrathecally to treat infections like meningitis when other routes are insufficient.