After a core needle biopsy, patients can typically resume normal activities within a day. There may be some soreness or bruising at the biopsy site, which can be managed with over-the-counter pain medications. Nurses should provide patients with detailed instructions on how to care for the biopsy site and what symptoms to watch for that might indicate a complication. Follow-up appointments may be scheduled to discuss the biopsy results and any further treatment or testing that may be required.