Nurses play a critical role in the early detection, management, and prevention of PRIS. Their responsibilities include: - Monitoring for early signs and symptoms of PRIS, such as metabolic acidosis and muscle weakness - Regularly checking laboratory values including CK, potassium, and lactate levels - Ensuring accurate medication records to track the duration and dosage of propofol infusion - Educating the healthcare team about the risks associated with prolonged propofol use - Implementing measures to prevent PRIS, such as using the lowest effective dose of propofol and limiting the duration of its use