Combined Hormone Replacement Therapy (HRT) refers to the use of both estrogen and progesterone hormones to alleviate symptoms associated with menopause. This therapy helps manage common menopausal symptoms such as hot flashes, night sweats, mood swings, and vaginal dryness. It is particularly prescribed for women who have not undergone a hysterectomy, as progesterone is essential to prevent the risk of endometrial cancer caused by estrogen alone.