Several factors can necessitate dose adjustments, including but not limited to:
Renal Function: Impaired kidney function can affect drug clearance, requiring dose reductions. Hepatic Function: Liver impairment can alter drug metabolism, necessitating dosage changes. Age: Pediatric and geriatric patients often need different dosages due to physiological differences. Weight: Dosages may need adjustment based on body weight to ensure therapeutic efficacy. Concurrent Medications: Other drugs can interact and affect drug levels, requiring dose modifications.
