Several neurological disorders involve microglia dysfunction:
- Alzheimer's Disease: In Alzheimer's, microglia fail to clear amyloid-beta plaques, contributing to the disease's progression. - Multiple Sclerosis: Microglia are involved in the inflammatory response that leads to the demyelination of neurons. - Traumatic Brain Injury: After an injury, microglia become activated and release cytokines, which can either aid in recovery or exacerbate damage.
