While generally safe, barium sulfate can cause various side effects and complications. Common side effects include: - Constipation: Barium sulfate can harden in the intestines, leading to constipation. Encourage patients to stay hydrated and consider recommending a mild laxative. - Abdominal Discomfort: Some patients may experience bloating or cramping. - Allergic Reactions: Though rare, allergic reactions can occur. Symptoms may include itching, hives, and difficulty breathing.