Clinical guidelines for FiO2 vary depending on the patient's condition. For instance, in acute settings, maintaining an FiO2 of 0.24 to 0.50 is often recommended to achieve a target arterial oxygen saturation (SpO2) of 94-98%. In chronic conditions like COPD, a lower FiO2 may be used to maintain SpO2 between 88-92% to avoid hypercapnia.
