Several challenges impede axon regeneration, particularly in the CNS:
1. Inhibitory Environment: The CNS has a more inhibitory environment due to the presence of certain molecules that prevent regeneration. 2. Scar Formation: Glial scar formation at the injury site can act as a physical barrier to regenerating axons. 3. Limited Intrinsic Capacity: CNS neurons have a limited intrinsic capacity for regeneration compared to PNS neurons.
