What Are Some Clinically Relevant ABC Transporters?
Several ABC transporters are clinically relevant, including: - P-glycoprotein (P-gp): Involved in the efflux of drugs like digoxin and chemotherapeutic agents. - Breast Cancer Resistance Protein (BCRP): Affects the pharmacokinetics of drugs such as methotrexate. - Multidrug Resistance-associated Proteins (MRPs): Involved in the transport of antiviral drugs and chemotherapeutic agents.
