Non-opioid analgesics refer to a class of medications used to manage pain without the use of opioids. They are commonly used for mild to moderate pain and can also be effective in more severe pain when used in combination with other therapies. These medications include acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen, and certain antidepressants and anticonvulsants.