Several disorders can affect white matter, including:
Multiple Sclerosis: An autoimmune disorder where the immune system attacks the myelin sheath, leading to demyelination and impaired signal transmission. Leukodystrophies: A group of rare genetic disorders that affect the growth or development of myelin. Vascular Dementia: Often results from small vessel disease, which can damage white matter and lead to cognitive decline. Traumatic Brain Injury (TBI): Physical trauma can lead to white matter damage, impacting cognitive and physical functions.