Protection: Cover the blister with a sterile dressing to prevent infection and further friction. Do Not Pop: Generally, it's advisable not to pop blisters to avoid infection. If necessary, it should be done under sterile conditions. Pain Relief: Administer pain relief medications as needed. Antibiotics: If an infection is suspected, topical or systemic antibiotics may be required. Hydration: Encourage adequate fluid intake for skin health and healing.