1. Identify a clinical problem: Start with a broad question or issue you want to address. 2. Break it down into PICO elements: Define the Patient, Intervention, Comparison, and Outcome. 3. Formulate the question: Combine these elements into a specific, focused question.
For example, a broad question like "What is the best way to manage pain in elderly patients?" can be broken down into a PICO question: "In elderly patients with chronic pain (P), does the use of acupuncture (I) compared to standard pain medication (C) reduce pain levels (O)?"