To apply the Rome Criteria in clinical practice, nurses should: 1. Take a detailed patient history: This includes documenting the frequency, duration, and nature of symptoms. 2. Perform a physical examination: This helps rule out other potential causes of the symptoms. 3. Use diagnostic questionnaires: Tools like the Rome IV Diagnostic Questionnaire can be invaluable. 4. Educate the patient: Inform the patient about the nature of their condition and the importance of adhering to treatment plans.