To administer saline nasal spray, follow these steps: 1. Wash your hands thoroughly. 2. Shake the bottle if required. 3. Tilt your head slightly forward. 4. Insert the nozzle into one nostril and close the other nostril with your finger. 5. Spray the solution while gently breathing in. 6. Repeat the process for the other nostril. 7. Avoid sneezing or blowing your nose immediately after application to allow the solution to work effectively.