The therapeutic index is calculated using the formula: \[ \text{TI} = \frac{\text{TD}_{50}}{\text{ED}_{50}} \] where: - \( \text{TD}_{50} \) is the dose that causes toxicity in 50% of the population. - \( \text{ED}_{50} \) is the dose that is therapeutically effective in 50% of the population.
