The implementation of EBP in nursing involves several steps. Initially, nurses need to formulate a clear and focused clinical question, often using the PICO format (Patient/Problem, Intervention, Comparison, Outcome). After defining the question, nurses conduct a thorough search for the best available evidence, appraise the quality of the research, and determine its applicability to their specific clinical setting. Once the evidence is appraised, it is integrated with clinical expertise and patient preferences to make informed clinical decisions. Finally, the outcomes of these decisions are evaluated, and the process is refined as necessary.