The digestive system plays a key role in nutrient transfer by breaking down food into smaller molecules that can be absorbed into the bloodstream. This involves several organs including the mouth, esophagus, stomach, intestines, and accessory organs like the liver and pancreas. Nurses need to understand the anatomy and physiology of the digestive system to effectively address issues such as malabsorption, gastrointestinal diseases, and the impact of medications on nutrient absorption.