Mutations in BRCA1 and BRCA2 significantly increase the risk of developing breast and ovarian cancer. Women with a BRCA1 mutation have a 55-65% risk of developing breast cancer by age 70, while those with a BRCA2 mutation have about a 45% risk. The risk for ovarian cancer is also elevated, with BRCA1 mutations conferring a 39% risk and BRCA2 mutations a 10-20% risk.
