Antipsychotic drugs work by altering the effects of neurotransmitters in the brain, particularly dopamine. Typical antipsychotics primarily block dopamine receptors, which can reduce symptoms of psychosis but may also lead to side effects like tardive dyskinesia. Atypical antipsychotics, on the other hand, act on both dopamine and serotonin receptors, often resulting in fewer motor side effects and better control of negative symptoms.