Hand Hygiene: Adhering to strict hand hygiene protocols is one of the most effective ways to prevent the spread of CRE. Isolation Precautions: Implementing and adhering to isolation precautions for patients known or suspected to have CRE. Environmental Cleaning: Ensuring that patient environments and medical equipment are thoroughly cleaned and disinfected. Antibiotic Stewardship: Promoting the appropriate use of antibiotics to reduce the development of resistance.