The application process involves several steps: 1. Wound Preparation: The wound bed is cleaned and debrided to remove any necrotic tissue. 2. Application: The skin substitute is carefully placed over the wound and secured with sutures, staples, or adhesive dressings. 3. Monitoring: The wound is monitored regularly for signs of infection, graft adherence, and overall healing. 4. Follow-Up Care: The patient may require additional treatments or adjustments to the skin substitute as healing progresses.