Syndrome of Inappropriate Antidiuretic Hormone Secretion (siadh) - Nursing Science

What is Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)?

Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) is a condition characterized by excessive release of antidiuretic hormone (ADH) from the pituitary gland or other sources, leading to water retention, hyponatremia, and hypoosmolarity. This can result in significant clinical complications if not managed appropriately.

Etiology and Pathophysiology

SIADH can be caused by a variety of factors including malignancies (such as small cell lung cancer), central nervous system disorders (like head injury or stroke), pulmonary diseases (like pneumonia), and certain medications (such as antidepressants and antipsychotics). The excessive ADH leads to increased water reabsorption in the kidneys, diluting the blood sodium levels.

Clinical Manifestations

The symptoms of SIADH can vary from mild to severe and may include:
Hyponatremia (low sodium levels)
Headache
Nausea and vomiting
Confusion
Seizures
Muscle cramps or spasms
Decreased urine output

Diagnostic Criteria

The diagnosis of SIADH is typically based on laboratory and clinical findings. Key diagnostic criteria include:
Low serum sodium (



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