Mechanism of Action
Rasagiline works by inhibiting the activity of the enzyme
monoamine oxidase B (MAO-B). This enzyme is responsible for breaking down
dopamine in the brain. By inhibiting MAO-B, rasagiline helps to increase and prolong the action of dopamine, which can help improve motor function in people with Parkinson's Disease.
Indications
Rasagiline is indicated for the management of the signs and symptoms of
idiopathic Parkinson's Disease as initial therapy alone (monotherapy) and as adjunct therapy with
levodopa.
Dosage and Administration
The typical starting dose of rasagiline for most patients is 1 mg taken once daily. It can be taken with or without food. Adjustments may be necessary based on the patient's response to the medication and the presence of any other underlying health conditions.Nursing Considerations
Nurses play a crucial role in the administration and monitoring of rasagiline therapy. Here are key nursing considerations: Monitoring Blood Pressure: Rasagiline can cause orthostatic hypotension. Monitor the patient's blood pressure regularly, especially during the initial phases of treatment.
Assessing Motor Function: Evaluate the patient's motor function to determine the effectiveness of the medication and adjust the dosage as necessary.
Dietary Restrictions: Patients should avoid foods high in
tyramine (e.g., aged cheeses, cured meats) to prevent hypertensive crises.
Medication Interactions: Be aware of potential interactions with other drugs such as
SSRIs,
SNRIs, and other
MAO inhibitors.
Patient Education: Educate patients and their families about the potential side effects and the importance of adhering to prescribed dietary restrictions.
Side Effects
Common side effects of rasagiline include headaches, joint pain, indigestion, and flu-like symptoms. More serious side effects may include severe hypertension, serotonin syndrome (especially when taken with antidepressants), and melanoma. It is essential to monitor patients closely for these adverse effects.Contraindications
Rasagiline is contraindicated in patients with known hypersensitivity to the drug or any of its components. It should not be used concurrently with other
MAO inhibitors or certain types of antidepressants due to the risk of severe reactions.
Patient Education
Patient education is a critical component of nursing care for those on rasagiline. Key points to cover include: Importance of Adherence: Emphasize the importance of taking the medication as prescribed.
Dietary Restrictions: Educate about avoiding foods high in tyramine.
Recognizing Side Effects: Inform patients about the potential side effects and instruct them to report any unusual symptoms immediately.
Drug Interactions: Advise patients to inform all healthcare providers about their use of rasagiline.
Conclusion
Rasagiline is an effective medication for managing Parkinson's Disease, but it requires careful monitoring and patient education. Nurses play a pivotal role in ensuring the safe and effective use of this medication through vigilant monitoring, patient education, and awareness of potential interactions and side effects.
