How Does Domperidone Work?
Domperidone works by blocking dopamine receptors in the gut and the brain. This action helps improve the movement of food through the stomach and intestines and also reduces feelings of nausea. By inhibiting dopamine, it can also increase the release of
prolactin, which is a hormone responsible for milk production.
Indications for Use
Domperidone is indicated for a variety of conditions, including:Dosage and Administration
Domperidone is usually taken orally, and the dosage can vary based on the condition being treated. For adults, the typical dosage ranges from 10 to 20 mg taken three to four times a day, usually 15 to 30 minutes before meals and, if necessary, before bedtime. It is important to follow healthcare provider instructions carefully to avoid potential side effects.Potential Side Effects
While domperidone is generally well-tolerated, some patients may experience side effects, including: Headache
Dry mouth
Abdominal cramps
Diarrhea
Galactorrhea (unexpected milk secretion)
Changes in menstrual periods
In rare cases,
cardiac arrhythmias and sudden cardiac death
Contraindications
Domperidone should not be used in certain populations, including: Patients with known hypersensitivity to domperidone
Individuals with a history of
prolonged QT interval Patients with moderate to severe hepatic impairment
Patients with existing gastrointestinal hemorrhage, obstruction, or perforation
Drug Interactions
Domperidone can interact with other medications, potentially increasing the risk of adverse effects. Healthcare providers should be cautious when prescribing domperidone with: Antifungal agents like ketoconazole
Antibiotics such as erythromycin
Antidepressants including fluoxetine
Other medications that prolong the QT interval
Nursing Considerations
Nurses play a crucial role in the administration and monitoring of domperidone. Key considerations include: Ensuring the correct dosage is administered as prescribed
Monitoring for signs of adverse effects, especially cardiac symptoms
Educating patients about potential side effects and what to do if they occur
Assessing the patient's overall condition and other medications to avoid interactions
Encouraging adherence to the medication regimen
Patient Education
Patient education is vital for the safe and effective use of domperidone. Key points to discuss with patients include: The importance of taking the medication before meals
Potential side effects and when to seek medical attention
The importance of informing healthcare providers about all other medications they are taking
Advising women who are breastfeeding about the potential benefits and risks
